Objective: To test if there are significant evidence-based differences in effectiveness between self-ligation (SL) and conventional-ligation (CL) brackets. Materials and Methods: Popular clinical claims of SL were identified through a literature overview of PubMed, EMBASE, Cochrane Library, and Web of Science for the period 1965-2017. Additional hand searching of the references from retrieved articles was completed. The articles containing the inclusion criteria were qualitatively analyzed using the Cochrane risk of bias tool, and one other scale. Applicable RCTs were statistically analyzed with weighted means calculations and forest plots. RCT data that could not be synthesized with one other RCT at this time were reserved for discussion.